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![]() Identify open reading frames (ORFs) with a single mouse click. ![]() Design and annotate primers for PCR, sequencing, or mutagenesis. Automatically annotate common features, or manually annotate coding sequences and other features. Search a DNA sequence to match either a DNA query, or a protein translation, or an annotation. Browse or print a DNA sequence and its annotations using customizable Map, Sequence, Enzymes, Features, Primers, and History views. Here are some of the things you can do with this software.Ĭreate a DNA sequence file by either entering a sequence, or importing a record from GenBank, or opening an annotated sequence stored in one of many common file formats. It is a great tool for both research and teaching. #SNAPGENE VIEWER CICRLCE MAP SOFTWARE#SnapGene Viewer is revolutionary software that allows molecular biologists to create, browse, and share richly annotated DNA sequence files up to 1 Gb in length. #SNAPGENE VIEWER CICRLCE MAP FOR MAC#SnapGene Viewer for Mac seems suited for biology labs or researchers who are looking for an efficient and ergonomic gene visualization solution that provides annotations and simulation of molecular biology procedures. A sample file is provided to let you quickly dig into the core functionality of the software and determine if it is right for you. On the plus side, annotations and viewing and searching functions are available on the demo and viewer versions. ![]() Unfortunately, the demo version won't let you test the actual simulations of molecular biology procedures. The program felt well engineered and stable. The viewer is free so you can communicate your work with colleagues with no need for additional licenses on their end. Many screenshots and feature descriptions that will help you learn more about the program and whether it's able to fulfill your needs are available at the developer's Web site. Six more videos are also available to explore advanced functions of this program. You are also invited to watch an introductory video to guide you through the basic functions of the software. At first launch a setup screen pops up that lets you define your preferred enzyme suppliers. Installing SnapGene Viewer for Mac is quick and easy. SnapGene Viewer for Mac helps you better visualize, annotate, and simulate DNA-related procedures. ![]() A complex field such as molecular biology requires efficient ways to visualize gene sequences and associated data. ![]() ![]() ![]() DIRT 4 PS3 RELEASE UPGRADEPlayers will be asked to upgrade their support staff, their PR, their sponsorships, and facilities that enhance all three. This is the hairiest series, especially in multiplayer, and requires a user to make precise entries into each turn of the first lap to have any shot at clearing the pack.ĭirt 4 encourages the user to try all of it with a persistent career layer that applies sponsorship goals and team branding to the car in every event. There is an officially branded World Rallycross championship, which is racing against a live field on real-world courses of variable surfaces. Then there's the Land Rush, which is a circuit course for buggies (most fun) trucks (fun, but always a crapshoot, which is still fun in its own way) and the inscrutable crosskarts (no fun). The timed, straight-ahead rally is Dirt 4's bread and butter, and it has two series, one for modern cars and another for heritage vehicles of the 1970s, 80s and 90s. There is still plenty of racing enjoyment in Dirt 4's less complex settings, but experienced racers will probably blow away a bot field rated anything less than tough, while newcomers stand little chance against the top setting. DIRT 4 PS3 RELEASE MANUALUnless the course is raced perfectly, beating a "tough" AI field requires using a manual transmission at minimum, and maybe other advanced options, to get off the line at top speed and recover from otherwise costly mistakes down the course. I found a big difficulty spike, though, between the fourth AI difficulty, "demanding" and "tough," its hardest setting. ![]() In Wales, I was allowed to skid off the outside shoulder of an open hairpin and, with my entire rear axle scrambling for traction like Scooby-Doo running away from a ghost, still make a clean getaway to first place. ![]() Getting into these adverse situations won’t fail the race, but you still have to extricate yourself from them. Racing a clean lap is always an admirable goal, but Dirt 4 knows the majesty of its sport is flat-out hooning through gritted teeth. Hatchback door banging, shredded tire throwing sparks, exhaust farting in the turns like a wild pony, I still snipped the finish line in a respectable third place in Australia. DIRT 4 PS3 RELEASE LICENSEDirt 4 was a license to sling gravel through every turn of a rally course, counter-steering to my heart's content. The dirty secret of all racing video games is that folks coast into the turns, drift, and occasionally brake by hitting a wall or an opponent. Simulation showcases these differences more, but even in the casual setting I felt like I could bias the braking, front or back, in my pre-race adjustments and give myself - and meaningfully use - a little less steer on pavement or a little more on gravel.ĭirt 4's fundamental appeal is in the reckless handling of rally racing, after all. There are still perceptible differences in the vehicle handling and surface traction on the easier Gamer setting. The game offers two handling settings to accommodate racers: Gamer, a more forgiving setup, and simulation, which is more challenging. Codemasters has been so trustworthy in this duty that the handling and traction of Dirt 4 can almost be taken for granted. Of course, it's essential to a racing game that the driving action be distinct and understandable across multiple vehicles classes and numerous surfaces, from taut blacktop to waterslide mud and dry, pillow-soft, well, dirt. The game's most profound strength is the unlimited variety and replayability offered by a simple course creation tool, which is well suited to rally racing's basic appeal: hurtling into something new and unknown with nerve, skill and flat-out speed. It will take care of the rest.Įxperienced, novice, casual, committed, car buff, adrenaline junkie or anything in between, Dirt 4 has a sweet spot for everyone and it takes no time to find it. Dirt 4 has just one expectation of its players: Enjoy racing. ![]() ![]() chooses to pay cash for the deal, then the SVA for its shareholders is simply the expected synergy of $1.7 billion minus the $1.2 billion premium, or $500 million.īut if Buyer Inc. The expected net gain to the acquirer from an acquisition-we call it the shareholder value added (SVA)-is the difference between the estimated value of the synergies obtained through the acquisition and the acquisition premium. is therefore $4 billion, representing a premium of $1.2 billion over the company’s preannouncement market value of $2.8 billion. They announce an offer to buy all the shares of Seller Inc. estimate that by merging the two companies, they can create an additional synergy value of $1.7 billion. Seller Inc.’s market capitalization stands at $2.8 billion-40 million shares each worth $70. is $5 billion, made up of 50 million shares priced at $100 per share. wants to acquire its competitor, Seller Inc. To see how that works, let’s look at a hypothetical example. More precisely, in stock transactions, the synergy risk is shared in proportion to the percentage of the combined company the acquiring and selling shareholders each will own. In stock transactions, that risk is shared with selling shareholders. The main distinction between cash and stock transactions is this: In cash transactions, acquiring shareholders take on the entire risk that the expected synergy value embedded in the acquisition premium will not materialize. But first let’s look at the basic differences between stock deals and cash deals. In this article, we provide a framework to guide the boards of both the acquiring and the selling companies through their decision-making process, and we offer two simple tools to help managers quantify the risks involved to their shareholders in offering or accepting stock. ![]() But when companies are considering making-or accepting-an offer for an exchange of shares, the valuation of the company in play becomes just one of several factors that managers and investors need to consider. Price is certainly an important issue confronting both sets of shareholders. It’s not that focusing on price is wrong. Both managers and journalists tend to focus mostly on the prices paid for acquisitions. In a cash deal, the roles of the two parties are clear-cut, but in a stock deal, it’s less clear who is the buyer and who is the seller.ĭespite their obvious importance, these issues are often given short shrift in corporate board-rooms and the pages of the financial press. What’s more, the findings show that early performance differences between cash and stock transactions become greater-much greater-over time. In studies covering more than 1,200 major deals, researchers have consistently found that, at the time of announcement, shareholders of acquiring companies fare worse in stock transactions than they do in cash transactions. The decision to use stock instead of cash can also affect shareholder returns. Companies that pay for their acquisitions with stock share both the value and the risks of the transaction with the shareholders of the company they acquire. In some cases, the shareholders of the acquired company can end up owning most of the company that bought their shares. But in an exchange of shares, it becomes far less clear who is the buyer and who is the seller. In a cash deal, the roles of the two parties are clear-cut, and the exchange of money for shares completes a simple transfer of ownership. This shift has profound ramifications for the shareholders of both acquiring and acquired companies. But just ten years later, the profile is almost reversed: 50 % of the value of all large deals in 1998 was paid for entirely in stock, and only 17 % was paid for entirely in cash. In 1988, nearly 60 % of the value of large deals-those over $100 million-was paid for entirely in cash. What is striking about acquisitions in the 1990s, however, is the way they’re being paid for. ![]() As markets globalize, and the pace at which technologies change continues to accelerate, more and more companies are finding mergers and acquisitions to be a compelling strategy for growth. After all, acquisitions remain the quickest route companies have to new markets and to new capabilities. ![]() Compare that with the 4,066 deals worth $378.9 billion announced in 1988, at the height of the 1980s merger movement. targets were announced for a total value of $1.63 trillion. In 1998 alone, 12,356 deals involving U.S. The legendary merger mania of the 1980s pales beside the M&A activity of this decade. ![]() |
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